Understanding Meloxicam interactions with other drugs, foods, and drinks is an essential factor for successful treatment. Numerous over-the-counter and prescription drugs are known to interact with this arthritis medication. Additionally, there are known Meloxicam interactions between the medicine and certain foods, and some diseases. A thorough understanding of these drug interactions, such as Meloxicam and Tylenol, can help make the medication’s use safer for the patient.

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Meloxicam and Tylenol (Acetaminophen)

Tylenol is the most popular brand name for acetaminophen. It is approved by the FDA in the management of mild to moderate pain and to reduce fever. As a result, it can be used for several health conditions that cause these symptoms.

Meloxicam belongs to a class of non-steroidal anti-inflammatory drugs (NSAIDs), while acetaminophen does not. It is not recommended to mix NSAIDs with other analgesics. Still, it is generally accepted that Meloxicam and Tylenol can be used if Mobic alone is not effective for arthritis pain. There are no significant interactions between Meloxicam and Tylenol. Regardless, it is advised to inform your medical doctor before using Meloxicam with Tylenol.


While combining these medications can result in Meloxicam interactions, they are mostly just mild in intensity. Mobic can cause the metabolism of diphenhydramine to be slowed down, which means that Benadryl may end up working for longer than intended.

Hydrocodone and Oxycodone

Hydrocodone and oxycodone are both opioid drugs used as pain relievers. They are prescription-only drugs typically reserved for severe pain or pain that is not resolved by other analgesics alone.

Similar complications may be observed when mixing Hydrocodone with different NSAIDs, such as when comparing Meloxicam versus Celebrex.

Mobic and oxycodone interaction includes a significant increase in the patient’s risk of experiencing complications with their gastrointestinal system. It is because NSAIDs and opioids both have specific GI complications that they cause. Combining the drugs has a larger effect on the gastrointestinal tract, which increases the chance of these effects occurring.

Speaking about Tramadol, which is also an opioid, it can sometimes be used together with NSAIDs and can even be more effective. However, Meloxicam and Tramadol combination should only be prescribed by the doctor.


It has been found that combining benzodiazepines, such as Xanax, with NSAIDs can reduce their efficacy in managing pain. For example, a study provided information showing that diazepam seemed to reduce the effectiveness of an NSAID in managing pain.

Other NSAIDs

It is best to avoid using Mobic with any other NSAID as it increases the risk of NSAID side effects occurring. It includes the likelihood of heart attacks, strokes, peptic ulcer disease, and GI bleeding. However, there may be rare instances where a medical doctor may approve this, such as using aspirin alongside Mobic in a person with arthritis and a history of heart disease.

Mobic and ibuprofen can combine to give serious drug interactions. It can significantly increase the risk of the adverse health effects of both NSAIDs, including complications with the individual’s digestive system, so only one of them should be taken.

Interactions With Food and Drinks

Mobic may cause interactions with certain food and drinks as well. Taking Meloxicam with alcohol is one of the most important interactions to be concerned about. Meloxicam, as well as its alternatives, prescription-only and OTC NSAIDs, may cause similar interactions with alcohol as well. Alcohol use with any form of the drug, oral or injection, may cause a higher risk of internal bleeding and other side effects, including peptic ulcer disease.

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How to Avoid Meloxicam Interactions

In some cases, combining Mobic with other oral drugs can be perfectly safe. Still, in other cases, it can significantly increase the risk of negative health effects or predispose to serious Meloxicam interactions. Therefore, it is better to use it exactly as detailed in the prescription information and only add other medications if approved by your medical doctor.

Page Sources

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